While you probably know exceptions to the breeds on this list, some dogs are more dangerous simply based on their size and force of their jaws.

Dogs have long been known as man’s (and woman’s) best friend. Canines are loyal and lovable, and they often provide comfort, protection and other services to their human counterparts. However, they can also be dangerous.

Depending on the animal’s upbringing, temperament and circumstances, any dog can be a threat. Even small dogs might bite someone. In fact, chihuahuas sink their teeth into vets more often than any other type of pooch.

But certain breeds can cause greater harm simply because of their size or the force of their jaws. Based on the damage they can do, these are some of the world’s most perilous pooches, in no particular order.

2Great Dane

Standing as high as 32 inches at the shoulder and taller than an adult human when on their hind legs, Great Danes tend to be sweet, friendly and patient with children. However, they are alert guard dogs as well. Great Danes have even caused fatalities.